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Pituitary dwarfism


Post-receptor defect. ⑤ target tissue is not sensitive to the IGF. 2 clinical manifestations of growth retardation: birth weight, length normal 5 months after birth, growth slowed down from there, since the beginning of the three-year-old physical development was slow, older, more behind the star, due to a tumor or other reasons due to secondary cases, where disease can start at the age of Wang children younger than appearance, proportionate parts of the body,[link widoczny dla zalogowanych], under the collar of small, short, thin neck, hand, foot and also less bone growth retardation: bone age retardation in children, the teeth later, the financial units of latency epiphysis,[link widoczny dla zalogowanych], delayed bone age is often more than 2 standard deviations (2SD) above. According to observations of different ages wrist, shoulder, elbow,[link widoczny dla zalogowanych], hip, knee and ankle joints to determine whether the skeletal age behind. Delayed puberty: age of puberty in children with no choice in the secondary sexual characteristics appear. Gonadal dysgenesis, the face of adult children remained. Such as child voice sounds sharp. Normal intellectual development: If accompanied by inadequate secretion of thyroid stimulating hormone can lead to mental retardation, posterior pituitary involvement may occur polydipsia, polyuria of diabetes insipidus symptoms. Patients with mental disorders often accompanied by short stature. 3 Diagnosis and differential diagnosis of saying off ① height than age,[link widoczny dla zalogowanych], same sex low 2SD above the mean annual height growth rate = ② <lIcm; in children of normal height and growth rate of 2 / 3 of the following ⑨ body symmetry, naive, normal intelligence. Some children may be associated with feces collapse disorder. ④ GH provocative test two drugs, GH peak <9.9gg / L. ⑤ bone age younger than 2 years old actually ⑨ dark except for thyroid dysfunction, chronic kidney disease and bone diseases. ⑦ head MRI showed reduced anterior pituitary. Differential diagnosis is required for all short of calling the patient's difficulties to understand the history of his mother, tent pregnancy, perinatal conditions, birth weight, nutritional status, growth and development history, disease, trauma, parents and family members, height, pubertal development, combined with a comprehensive physical examination and laboratory data identification. Dr Wong loving kohlrabi hide search ① Familial short stature: tall parents have shorter d, JL third percentile in height and often Constitution of delayed puberty: male more common in the age of 1 to 2 were growth retardation. backwardness and bone age delayed puberty. of the parents usually have a similar history, but final height is still normal. @ intrauterine growth retardation: birth length, weight were lower than the tenth percentile age. The 4, JL length, weight was always lower than the normal development of children and more as placental dysfunction, or intrauterine infection caused by the retardation of fetal Fu @ stomach skeleton developmental disorders: a variety of bone, achondroplasia and others have special skills spider body appearance, clinical is not difficult to identify. @ the pool: chromosomal abnormalities such as Turner syndrome. In addition to 21 blue body syndrome, accompanied by short stature outside the intelligence behind. special face, identification does not stack heart, liver, kidney and other chronic diseases, long-term nutrition is not stupid, inherited metabolic disease and other diseases, such as by history revolves polysaccharides can be identified. 4 pre-treatment and final height. deletion of GH therapy for 『t: either primary or secondary GH deficiency may be of short-ho with GH therapy, recombinant human growth hormone (R_hGH) has been widely used in the treatment of this disease, age at start of treatment effect of the smaller birds for a good, therapy should continue until osteophiphysis date; the first In the best, long-term use, growth slowed, the growth rate from the original% 4cm / years to accelerate to 9.2 ~ 13.7cm / year, average annual growth lZem. At present, most scholars recommended dosage is 0.5 ~ 0 .7u/kg · weeks. every night before bed Sheng: injection. GH treatment of the individual may have adverse local reactions. Low thyroid cable (, r1) hyperinsulinemia. producer prices as high clinical RhGH widely limited. Anabolic steroid hormones can accelerate growth based on the current use of such drugs 『J5 used Nandrolone phenylpropionate, 1H / I 【g. maximum of 25mg, l ~ 2 times a week, l5 ~ 20 times as a course of treatment, each course interval of 6 months. can also be used testosterone propionate, Fu J with 1 per volume, each 12.5 - 25mg, 6 months for a course of treatment, an interval of 6 months, the medicines have a greater promotion of epiphyseal healing, bone age requirements and the actual age gap behind at least 3 years Since these drugs speed up the epiphyseal fusion, final height is lower than the same age group. Long bone growth depends on the height changes, including calcification, bone shape than the center and the final fusion of the epiphysis, it can be developed to predict the height from the epiphyses, sheaths commonly used as indicators of the epiphysis epiphyseal growth despite individual differences, but there are certain special law. Clinical often used in the wrist, the universe, time, hip, foot, peptone-related x-ray to determine bone age, height prediction
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