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Serum tumor markers CA242,[link widoczny dla zalogowanych], CEA joint inspection in the diagnosis of digestive tract cancer


: R446,[link widoczny dla zalogowanych], 11 Document code: B Article ID: 10045627 (2091) 040013O1 carbohydrate antigen (CA242), drops antigen (CEA) as a tumor marker in the diagnosis of digestive tract cancer has been widely used and become a clinical E efficacy, an important means of monitoring the recurrence of uJ. In this paper, solid-phase enzyme-linked immunosorbent assay lr132 cases (including the normal eight, gastric cancer, colon cancer patients) serum CA242, CEA levels of CA242, CEA joint inspection of the clinical diagnosis of gastrointestinal cancer. 1 object control group of 35 patients were healthy hospital, male 2l cases. 14 women down,[link widoczny dla zalogowanych], aged 28 to 62 years, mean 44 years old. Digestive tract cancer group: 97 cases, including 5 patients with colorectal cancer down, male 32, female 23 down, aged 25 to 68 years, mean 4g years old; 42 patients with gastric cancer down. 30 males and 12 females, aged 23 to 71 years, an average of 46 years. Tumors were seized on hospital in-patients by clinical, chest radiograph, B ultrasound, endoscopy,[link widoczny dla zalogowanych], CT diagnosed in some patients after surgery by the pathology. 2 Methods 2.1 fasting venous blood 3nat, 3000rpm centrifuge 10min, serum was separated under test is set for a 20C refrigerator storage. 2.2CA242, CEA was measured by solid phase enzyme-linked immunosorbent assay,[link widoczny dla zalogowanych], CA242 kit products for the Swedish CanAg, CEA kit products for the U.S. Bioceed, testing procedures carried out according to kit instructions to determine the result: The CEA:> 2. 5g / L, CA242> 20U/ml as positive community values, with the f test analysis of differences. 3 Results 3.1 gastrointestinal cancer group and control group shown in Table Table 1 Determination of the digestive tract swelling capsule Tam determination results with the control group (; ±) Note: 1) Compared with the control group, P <0.013 .22 indicators positive rate of the JIU issued on the date shown in Table 2, animal husbandry About :2001-0823; Hu Minhua (1964). Female, head technician testing positive rates in Table 2 () 4 gastrointestinal cancer experience a high incidence in China, its diagnosis is also a lot of serum tumor markers such as CA242, CEA, CA19-9, CA A 50, AFP and other mouth 』, but street of single detection rate was low, to compensate for a single potential markers in the tumor samples in the lack of sensitivity and specificity, using 2 or 2 on the Markers and related clinical dynamic observation of tumor markers of changes, not only can improve the detection rate of malignant tumors, but also for the clinical assessment of efficacy, recurrence monitoring information. CA242 is a sialylated carbohydrate protein in healthy individuals and patients with benign diseases of the vertebral content of low risk of gastrointestinal malignancy, elevated serum CA242 levels, can be seen from Table 1, gastric cancer, serum CA242 in patients with colorectal cancer concentration compared with the control group were significantly different (P <O.01) {while CEA is present in cancer tissue and embryo League organizations in a sticky protein j, in the digestive tract can be seen in cancer patients increased. This determination of CEA levels in gastric cancer patients compared with normal control group was significant difference (P <0.o1), while the concentration of patients with colorectal cancer cEA compared with the control group although no significant difference, but a higher positive rate was 65.45, compared with the control group showed significant differences (P <o.01) can be seen from Table 2, the use of CEA and CA242 JIU make their gastric cancer, colorectal cancer, the positive detection rate increased to 78. 57,78.18 than two single test has significantly increased, CA242 and CEA respect we recommend the JIU. With the extensive use of tumor markers, not only will it as a clinical indicator of tumor, more importantly, is used to assess efficacy, Jiance prognosis of recurrence and speculation, so we are using a variety of markers of joint inspection, depending on the tumor, fine some excellent marker for selection and rational combination of them, to meet clinical needs.
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